丁二酸(butanedioic acid)，广泛存在于动植物和微生物体内，是 TCA 循环的 中间产物之一,是工业上一种重要的四碳化合物。它作为有机合成原材料、中间产 物或专用化学品广泛应用于食品、医药、农药、染料、香料、油漆、塑料和材料 工业。生物法制取丁二酸是完全与传统方法不同的工艺，同从石油中提取丁二酸 工艺相比，生物法具有环保，价优的特点，是生物循环的成功范例。在江阴市创 业园实施 1000 吨级生物法制备丁二酸项目是否可行是值得研究的。 本研究的第一章说明了生物法生产丁二酸是一个工艺创新，丁二酸是一种重 要的化工基础原料，其国内外市场容量巨大，本章对目前世界各国，以及国内对 生物法生产丁二酸的研究水平进行了相关的综述以及丁二酸的延伸物的发展和市 场的需求、生产情况进行了论述，特别是延伸物的增长速度非常快，这个支撑了 丁二酸的市场和价格，另对项目地点江阴市创业园生物研发基地强大的支持能力， 说明了实施本项目的必要性以及编制本研究报告的产业和技术来源依据。第二章 对项目建设的选址、工艺路线、原材料的选用及可行性进行了研究。证明了江阴 在气候、水文、地质、交通等条件是满足项目要求，项目的工艺路线选择是合理 的原材料选用蜜糖等是经济合理的。第三章、第四章对项目设计的环境保护、安 全生产、以及企业的组织进行了研究，这些措施将使项目实施完全符合环保、安 全、劳保等部门的要求。第五章、第六章、第 7 章对项目资金的来源、使用、回 报、现金流的按排、内部收益率的考核进行了研究。并对项目的经济效益进行了 分析，给出项目的财务评价，从经济技术角度分析出项目在财务上风险不大。第 8 章得出在江阴创业园生物研发基地实施本项目是符合国家产业政策，经济合理 的，在该基地实施生物法制备丁二酸项目采用的中科院研发的工艺流程和菌种是西安建筑科技大学硕士学位报告 一种高效先进的工艺。项目实施后取得的经济效益也是客观的，项目的回收期也 是符合一般项目的要求的。并对项目相应的经济技术指标进行归纳。 关键词，生物法；丁二酸；可行性；安全；环保；经济西安建筑科技大学硕士学位报告 Biological preparationof Succinic acid project Feasibility study Specialty: Business Administer Name: Xue Qing yu Instructor: Qiu Guo fang Abstract Succinic acid ( butanedioic acid ), widely exists in plants and microorganisms, is a TCA loop intermediate product, is the industry an important four carbon compounds. It as organic synthesis raw materials, intermediate products or chemicals are widely used in food, medicine, pesticides, dyes, spices, paint, plastics and materials industry. Biological preparation of succinic acid is completely different from the traditional method of the process, the oil extracted from succinic acid process, biological process with environmental protection, excellent price of the characteristics, is a successful example of biological cycle. In Jiangyin city park to carry out 1000tons of biological preparation of succinic acid project is feasible is worthy of study. The study of the first chapter illustrates the biological production of succinic acid is a technology innovation, succinic acid is an important chemical raw materials at home and abroad, its huge market capacity, the chapter on current world, and home to the biological production of succinic acid levels were related to the review and extension of succinic acid the development and market demand, production were discussed, especially the extension of the growth rate is very rapid, the support of the succinic acid Market and price, the other on the project site in Jiangyin city business park of biological research and development base of strong support, the implementation of the project the necessity as well as the preparation of the report industry and technology sources. The second chapter of the project site selection, process route, the selection of raw materials and feasibility research. Shown in Jiangyin in climate, hydrology, geology, traffic condition is satisfied the requirement of project, project selection of process route is the reasonable selection of raw西安建筑科技大学硕士学位报告 materials such as honey is economically reasonable. The third chapter, the fourth chapter on the project design, production safety, environmental protection and enterprise organization was studied, these measures will enable the implementation of the project in full compliance with environmental protection, safety, labor protection and other departments of the requirements. The fifth chapter, sixth chapter, seventh chapter of the source, the use of project funds, return, cash flow by the row, internal rate of return of the assessment were studied. And to the economic benefits of the project were analyzed, given the financial evaluation of the project, from the economic angle analysis of project financial risk is. The eighth chapter obtains in the Jiangyin business park of biological research and development base for the implementation of the project is in line with the national industrial policy, economic and reasonable, at the base of the implementation of biological preparation of succinic acid were used to project the CAS research and development process and the strain is a highly advanced technology. After the implementation of the project to obtain economic benefit is objective, the project payback period is consistent with the general requirements of the project. And the corresponding economic and technical index of project author. Keywords: biological method , butanedioic acid , feasibility ,safety,environmental protection ,economic西安建筑科技大学硕士学位报告 I 目 录 1 绪论 ............................................................................................................................ 1 1.1 项目提出的背景及必要性 .............................................................................. 1 1.2 项目概况 .......................................................................................................... 4 1.3 国内外市场分析 .............................................................................................. 6 1.4 编制本报告的主要依据 ................................................................................ 19 2 项目建设的主要条件 .............................................................................................. 21 2.1 建设的地址 .................................................................................................... 21 2.2 厂址建设条件 ................................................................................................ 21 2.3 建设规模 ........................................................................................................ 22 2.4 工艺技术方案 ................................................................................................ 22 2.5 主要工艺设备及选型 .................................................................................... 27 2.6 主要原料需用量及供应 ................................................................................ 30 3 公用工程与环境治理 .............................................................................................. 31 3.1 公用工程 ........................................................................................................ 31 3.2 建设地点环境现状 ........................................................................................ 32 3.3 污染物排放及治理方案 ................................................................................ 33 4 企业组织和职业安全 .............................................................................................. 35 4.1 企业组织 ........................................................................................................ 35 4.2 人力资源配置及管理 .................................................................................... 35 4.3 安全生产及卫生防护 .................................................................................... 36 5 投资估算及资金筹措 .............................................................................................. 39 5.1 投资估算依据及说明 .................................................................................... 39 5.2 资金筹措 ........................................................................................................ 40 6 经济效益分析 .........................................................................